Glossary of Terms

A medical doctor who has special training in identifying diseases by studying cells and tissues under a microscope.

A medical report that describes the characteristics of a tissue specimen that is taken from a patient. The pathology report is written by a pathologist, a doctor who has special training in identifying diseases by studying cells and tissues under a microscope. A pathology report includes identifying information (such as the patient’s name, birthdate, and biopsy date) and details about where in the body the specimen is from and how it was obtained. It typically includes a gross description (a visual description of the specimen as seen by the naked eye), a microscopic description, and a final diagnosis. It may also include a section for comments by the pathologist. The pathology report provides the definitive cancer diagnosis. It is also used for staging (describing the extent of cancer within the body, especially whether it has spread) and to help plan treatment.

A lymph node in the pelvis. The pelvis is the area of the body below the abdomen that contains the hip bones, bladder, rectum, and male or female reproductive organs. Pelvic lymph nodes drain and filter lymph from the pelvis and nearby areas. In cancer, pelvic lymph nodes that are near a tumor may be removed by surgery to check for signs that cancer has spread.

A form of immunotherapy.

The PET and CT scans are done at the same time with the same machine. The combined scans give more detailed pictures of areas inside the body than either scan gives by itself.

A laser energy to activate drugs in the prostate that then kills the cells nearby.

A substance or intervention that looks the same and is used or taken the same way as the active drug that is being tested.

A type of radiation therapy in which a radioactive isotope is bound to a molecule that will attach to cancer cells that express PSMA, allowing the radiation to damage or kill these cells. Pluvicto is administered intravenously.

The likely outcome or course of a disease; the chance of recovery or recurrence.

The spreading or worsening of cancer in the body.

A walnut-shaped gland that produces fluid for semen. Located between the base of the penis and the rectum.

PSA is a protein made by the prostate gland. The amount of PSA may be higher in men who have prostate cancer, benign prostatic hyperplasia (BPH), or infection or inflammation of the prostate.

A laboratory test that measures the amount of prostate-specific antigen (PSA) found in the blood. PSA is a protein made by the prostate gland. The amount of PSA may be higher in men who have prostate cancer, benign prostatic hyperplasia (BPH), or infection or inflammation of the prostate. Also called PSA test.

These proteins grow on the surface of prostate cancer cells and can be a biomarker of prostate cancer. PSMA proteins can be used as targets for radioactive isotopes, which can identify cancer cells on a PET scan or potentially destroy them.

A condition where the prostate cancer cells show changes when viewed under a microscope. High-grade PIN means the cell pattern is abnormal and the cells could be pre-cancerous.